The main psychoactive components of traditional “magic” mushrooms, found in the genus Psilocybe, are psilocybin and psilocin. I’m a natural product scientist at Pennsylvania State University, where my lab specializes in understanding the molecules found in plants, mushrooms, and other natural resources, and how they can benefit or harm human health. If you’re interested in trying psychedelics, consider talking with a healthcare professional about options for psychedelic-assisted therapy in your area. For example, the Food and Drug Administration (FDA) recently warned about a product line containing a propriety blend of mushrooms intended for microdosing.
In comparison to previous studies 37, 38, most results remained negative even when the statistical analyses were restricted to measurements obtained from unblinded subjects (with the exception of the VAS total scores of acute effects, see Fig. 2A). In particular, Van Elk et al. found that more than 60% of the participants were breaking blind to the experimental condition , consistent with the unblinding rate found in our study (75%). Family et al. established the safety of LSD microdosing in older volunteers, but did not report substantial positive effects . Another study by the same group showed that a low dose of LSD (13 µg) increased amygdala seed-based connectivity with the right angular gyrus, right middle frontal gyrus, and the cerebellum, and decreased amygdala connectivity with the left and right postcentral gyrus and the superior temporal gyrus. At the highest dose, the drug increased ratings of vigor and slightly decreased positivity ratings of images with positive emotional content. We did not find differences (uncorrected) between the active dose and placebo conditions.
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